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it is important to instruct patients and caregivers on the proper use of the transdermal patch, particularly that: Join dementia research. (2019). About the service. [online] Available at: https://www.joindementiaresearch.nihr.ac.uk/content/about [Accessed 4 Jul. 2019]. You May Not Remember But I Will Never Forget Alzheimer Sweatshirt, Alzheimer's Awareness Sweatshirt, Alzheimer's Awareness Hoodie Prince, M. et al. (2014). Nutrition and Dementia: a review of available research. Alzheimer’s Disease International. London. [online] Available at: https://www.alz.co.uk/nutrition-report [Accessed 4 Jul. 2019]. If you are allergic to rivastigmine patch; any part of rivastigmine patch; or any other drugs, foods, or substances. Tell your doctor about the allergy and

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In Vascular dementia, your GP may suggest taking medication if you have high blood pressure, raised cholesterol or diabetes. It is also helpful to stop smoking, eat healthily and take regular exercise. Estrogen-containing oral contraceptives have been shown to significantly decrease plasma concentrations of lamotrigine when co-administered due to induction of lamotrigine glucuronidation. This may reduce seizure control. Although the potential interaction between estrogen-containing hormone replacement therapy and lamotrigine has not been studied, it is expected that a similar interaction exists, which may lead to a reduction in seizure control among women taking both drugs together. Therefore, dose adjustment of lamotrigine may be necessary.There are no clinical data on exposed pregnancies. Studies in animals have not shown reproductive toxicity. Neurotransmitters are stored in nerve cells in the brain and nervous system, and are involved in transmitting messages between the nerve cells. They are necessary for the normal functioning of the brain and nervous system. Acetylcholine in the brain is continually being released by nerve cells, and then broken down by another natural chemical called acetylcholinesterase. Alzheimer’s Society. (2019). Driving and dementia. [online] Available at: https://www.alzheimers.org.uk/get-support/staying-independent/driving-and-dementia [Accessed 4 Jul. 2019].

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This is caused by a reduced blood supply to the brain, due to damaged blood vessels. This means that parts of the brain do not get enough oxygen and nutrients, and so brain cells die. During clinical trials with patients treated for hepatitis C virus (HCV) infections with the combination regimen ombitasvir/paritaprevir/ritonavir with and without dasabuvir, ALT elevations greater than 5 times the upper limit of normal (ULN) were significantly more frequent in women using ethinylestradiol-containing medicinal products such as CHCs. Additionally, also in patients treated with glecaprevir/pibrentasvir, ALT elevations were observed in women using ethinylestradiol-containing medications such as CHCs. Women using medicinal products containing oestrogens other than ethinylestradiol, such as estradiol, had a rate of ALT elevation similar to those not receiving any oestrogens; however, due to the limited number of women taking these other oestrogens, caution is warranted for co-administration with the combination drug regimen ombitasvir/paritaprevir/ritonavir with or without dasabuvir and also the regimen glecaprevir/pibrentasvir. See section 4.5. Combined oestrogen-progestogen and oestrogen-only therapy are associated with an up to 1.5-fold increase in risk of ischaemic stroke. The relative risk does not change with age or time since menopause or duration of use. However, as the baseline risk of stroke is strongly age-dependent, the overall risk of stroke in women who use HRT will increase with age (see section 4.8). Prince, M. et al. (2014). World Alzheimer Report 2014. Dementia and Risk Reduction. An analysis of Protective and Modifiable Risk Factors. Alzheimer's Disease International, London UK. [online] Available at: https://www.alz.co.uk/research/WorldAlzheimerReport2014.pdf [Accessed 4 Jul. 2019]. pp. 42-63.Prince, M. et al. (2014). World Alzheimer Report 2014. Dementia and Risk Reduction. An analysis of Protective and Modifiable Risk Factors. Alzheimer's Disease International, London UK. [online] Available at: https://www.alz.co.uk/research/WorldAlzheimerReport2014.pdf [Accessed 4 Jul. 2019]. pp. 66-83. The risk of coronary artery disease is slightly increased in users of combined oestrogen-progestagen HRT over the age of 60 (see section 4.4). National Institute on Aging. (2017). What Happens to the Brain in Alzheimer’s Disease? [online] Available at: https://www.nia.nih.gov/health/what-happens-brain-alzheimers-disease [Accessed 4 Jul. 2019]. National Institute for Health and Care Excellence. (2018) Dementia: assessment, management and support for people living with dementia and their carers. Nice guideline 97. [online] Available at: https://www.nice.org.uk/guidance/ng97/chapter/Recommendations#diagnosis [Accessed 4 Jul. 2019]. Standard 1.2.13.