Sherif S, Bendas ER, Badawy S. The clinical efficacy of cosmeceutical application of liquid crystalline nanostructured dispersions of alpha lipoic acid as anti-wrinkle. Eur J Pharm Biopharm. 2014;86(2):251-9. doi:10.1016/j.ejpb.2013.09.008

Gleiter, C. H., Schug, B. S., Hermann, R., Elze, M., Blume, H. H., and Gundert-Remy, U. Influence of food intake on the bioavailability of thioctic acid enantiomers. Eur.J Clin Pharmacol. 1996;50(6):513-514. View abstract. Is it “essential” that you consume a certain dosage of alpha lipoic acid every day? Not exactly, which is why it’s not considered an “essential nutrient.”A small pilot study was conducted administering ALA 150 mg 3 times daily to 10 HIV-infected patients. ALA increased glutathione in all patients and vitamin C in most patients. In addition, it improved the T-helper lymphocyte to T-helper suppressor cell ratio in 6 patients.( 2) Be cautious with this combination • Medications for cancer (Antitumor antibiotics) interacts with ALPHA-LIPOIC ACID

Alpha lipoic acid can protect cells and neurons involved in hormone production, offering protection against type 2 diabetes. Akbari M, Ostadmohammadi V, Lankarani KB, et al. The effects of alpha-lipoic acid supplementation on glucose control and lipid profiles among patients with metabolic diseases: a systematic review and meta-analysis of randomized controlled trials. Metab Clin Exp. 2018;87:56-69. doi:10.1016/j.metabol.2018.07.002 Huang, E. A. and Gitelman, S. E. The effect of oral alpha-lipoic acid on oxidative stress in adolescents with type 1 diabetes mellitus. Pediatr.Diabetes 2008;9(3 Pt 2):69-73. View abstract.Dementia in people with advanced HIV/AIDS. Taking alpha-lipoic acid by mouth has no effect on thinking problems in people with HIV.

Shinto L, Quinn J, Montine T, et al. A randomized placebo-controlled pilot trial of omega-3 fatty acids and alpha lipoic acid in Alzheimer's disease. J Alzheimers Dis. 2014;38(1):111-20. doi:10.3233/JAD-130722 Evans, JL and Goldfine, ID. Alpha-lipoic acid: a multifunctional antioxidant that improves insulin sensitivity in patients with type 2 diabetes. Diabetes Technology and Therapeutics 2000;2(3):401-413.You’re taking any medications for diabetes for insulin control, since this can raise the risk for hypoglycemia and low blood sugar.

Alpha lipoic acid — one kind of antioxidant — is a type of compound found in plant foods we commonly eat. Results from certain studies demonstrate that long-term use of ALA can halt oxidative damage that can result in modified DNA in the retina. As people age, their vision becomes much more compromised, which is why it’s important to eat a nutrient-dense diet well before old age to prevent degeneration of eye tissue or vision loss early on. Chen LY, Zhang YD & Zhu FY. Effects of alpha lipoic acid and prostaglandin E1 on diabetic peripheral neuropathy. Journal of Practical Diabetology 2008;4:50-51. A 2020 meta-analysis of placebo-controlled trials also found that ALA treatment significantly reduced BMI and body weight and may protect against obesity. Similarly, a 2017 double-blind, placebo-controlled trial found that oral administration of ALA (1,200 mg/day) for eight weeks induced mild weight loss accompanied by a reduction in waist circumference. Risks and Side Effects No adverse reactions have been reported; however, hypersensitivity reactions have occurred. ToxicologyAlpha lipoic acid (also called ALA or thioctic acid) is a type of compound found in many plant foods and in supplement form. The body also makes some ALA on its own. ALA’s most valuable role in the body is fighting the effects of free radicals, which are dangerous, chemical-reaction byproducts that form during the process of oxidation. Within our cells, ALA is converted into dihydrolipoic acid, which has protective effects over normal cellular reactions, such as those involved in metabolic functions and neuron signaling. Altunina NV, Lizogub VG, Bondarchuk OM. Alpha-lipoic acid as a means of influence on systemic inflammation in type 2 diabetes mellitus patients with prior myocardial infarction. J Med Life. 2020;13(1):32-36. doi:10.1186/1758-5996-6-80