To understand the anatomy of a breakthrough case, it’s helpful to think of the human body as a castle. Deepta Bhattacharya, an immunologist at the University of Arizona, compares immunization to reinforcing such a stronghold against assault. Yet it is just as clear, as Allison is happy to point out, that he didn’t do it alone. Many prominent researchers contributed to our understanding of immune regulation. It was a team of French researchers that discovered CTLA-4. Sarah Townsend showed that the immune system can fight cancer. Jedd Wolchok and his team recruited patients and performed clinical trials. El autor entrelaza ingeniosamente estudios científicos, anécdotas y entrevistas para explicar que las adversidades son parte de la vida y sentirse atascado es una característica más que un problema en el camino hacia el éxito. Afortunadamente, podemos superar el estancamiento y alcanzar nuestros objetivos más elevados implementando los ajustes y correcciones adecuados. Adam Alter marries research-based solutions with genuine insight. This book is an invaluable guide to turning hurdles into breakthroughs." —Scott Galloway, NYU Stern professor of marketing and author of Adrift Over the next two decades, he became a highly respected researcher and made some notable discoveries in the field of immune regulation. It was slow, painstaking work, identifying the myriad different receptors that govern the human immune system, decoding the structure of their proteins and inferring how they functioned together.

Anatomy of a Breakthrough By Adam Alter | New | 9781788706209

A deeply researched and compelling guide to breaking through the inevitable obstacles on the path to meaningful accomplishment." —Cal Newport, New York Times bestselling author of Digital Minimalism and Deep Work

Post-vaccination infections, or breakthroughs, might occasionally turn symptomatic, but they aren’t shameful or aberrant. They also aren’t proof that the shots are failing. These cases are, on average, gentler and less symptomatic; faster-resolving, with less virus lingering—and, it appears, less likely to pass the pathogen on. The immunity offered by vaccines works in iterations and gradations, not absolutes. It does not make a person completely impervious to infection. It also does not evaporate when a few microbes breach a body’s barriers. A breakthrough, despite what it might seem, does not cause our defenses to crumble or even break; it does not erase the protection that’s already been built. Rather than setting up fragile and penetrable shields, vaccines reinforce the defenses we already have, so that we can encounter the virus safely and potentially build further upon that protection. That’s why collaboration is becoming a key competitive advantage. Clever individuals working alone can tweak around the edges, but to solve a really big problem requires a collective effort. You need experts and outsiders, managers and researchers, engineers, marketers, logistics specialists and others as well. When Jim Allison walked into that office in 2004, it didn’t mark the beginning or the end of the journey, but the middle. We still have a long way to go. La solución propuesta por el autor se basa en un proceso que él llama: auditoría de fricción, un procedimiento sistemático para entender por qué una persona u organización está estancada y cómo avanzar superando tres fuentes de fricción: las emociones inútiles, los patrones de pensamiento inútiles y los comportamientos inútiles.

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I was impressed with this book from the beginning to end. Alter's writing style is easy to understand. Adam Alter marries research-based solutions with genuine insight. This book is an invaluable guide to turning hurdles into breakthroughs. * Scott Galloway, NYU Stern professor of marketing and author of Adrift * My experience in later years showed that had I taken rest, just lay down in bed for three days tops, I would have easily become normal. The best examples of this come from elite athletes who sacrifice immediate performance for long-term dominance. For example, the greatest soccer player today (and perhaps ever), Lionel Messi, walks for the first few minutes of every game as he soothes his nerves and develops a sense of how the other 21 players on the field are behaving. He has never scored during the first two minutes of any game but has scored during every single other minute from three to ninety. That two-minute sacrifice pays dividends during the remaining eighty-eight-plus. “The idea here is to take a beat—whether a minute or a day or a week—before you act.” Join us for a conversation between NYU Stern professor Scott Galloway and bestselling author Adam Alter, where they’ll discuss:

The amount of research he did to write this book is also followed up at the end for further reading. At some point in the journey of existence, there comes a moment when the weight of monotony and stagnation holds sway, as individuals find themselves ensnared in a relentless cycle of sameness. It's a feeling that resonates with countless souls, a gnawing sense that there must be more to life. Make Your Bed: Little Things That Can Change Your Life...And Maybe the World by William McRaven (2017) Allison was excited. He began to fly around the country presenting his results to all of the top pharmaceutical companies, but none showed interest. Over the years, they had spent billions on immunological approaches to cancer and weren’t ready to take another plunge. “It was depressing,” he told me. “I knew this discovery could make a difference, but nobody wanted to invest in it.”